刘亚锋，安徽理工大学，公共卫生学院，博士研究生中共党员，河南许昌，学科专业：职业健康安全。

教育经历：

（1）2025-03 至 2025-06, 南洋理工大学, 访学；

（2）2022-09 至 今, 安徽理工大学, 职业健康安全, 博士；

（3） 2019-09 至 2022-06, 安徽理工大学, 影像医学与核医学, 硕士；

（4）2014-03 至 2017-01, 郑州大学, 临床医学, 学士。

近五年主持或参加的基金项目/课题：

（1）基于机器学习和影像组学预测肺癌放疗疗效的研究。安徽理工大学2020年研究生创新基金项目，2021-01-01 至 2022-5-31，主持；

（2）胸部CT生境分析识别尘肺病高危人群。安徽理工大学2022年研究生创新基金项目，2023-01-01 至 2026-5-31，主持；

（3）基于人工智能和多模态构建粉尘环境工作者早期AD预警模型。煤炭安全精准开采国家地方联合工程研究中心项目，2024-01-01 至 2025-12-31，主要参与人（第三）。

专业经验:

（1）影像数据类:影像学结合人工智能技术在各类疾病中的早期诊疗的应用；

（2）生物信息学:挖掘各类疾病的潜在诊断和治疗靶点；

（3）临床医学数据类:临床预测模型、横断面和回顾性分析。

未来聚焦方向:

依托大健康方针和策略，结合各类新兴组学技术、大数据信息以及人工智能技术方案，实现疾病的早期筛查和诊断；其次将组学数据与细胞和动物实验相结合，研究疾病的发生机制；最终，开发具有实际应用价值的疾病的早期预防的转化产品。

代表性研究成果和学术奖励情况：

一、代表性论著：

(1)Liu Y, Wu J, Zhou J, Guo J, Ren D, Bai Y, Hu D. TFCP2 is recognized as a dynamic monitoring index of pneumoconiosis by combining radiomics with transcriptomics. Int Immunopharmacol. 2025 Apr 24;153:114457. doi: 10.1016/j.intimp.2025.114457. （中科院2区）

(2)Liu Y, Han T, Xu Z, et al. CDC45 promotes the stemness and metastasis in lung adenocarcinoma by affecting the cell cycle. J Transl Med. 2024;22(1):335. Published 2024 Apr 8. doi:10.1186/s12967-024-05038-5.（中科院2区TOP）

(3)Liu Y, Wu J, Zhou J, et al. Identification of high-risk population of pneumoconiosis using deep learning segmentation of lung 3D images and radiomics texture analysis. Comput Methods Programs Biomed. Published online January 4, 2024. doi:10.1016/j.cmpb.2024.108006.（中科院2区TOP）

(4)Liu Y, Han T, Miao R, et al. RACGAP1 promotes the progression and poor prognosis of lung adenocarcinoma through its effects on the cell cycle and tumor stemness. BMC Cancer. 2024;24(1):7. Published 2024 Jan 2. doi:10.1186/s12885-023-11761-x.（中科院2区TOP）

(5)Liu Y, Han T, Wu J, et al. SPOCK1, as a potential prognostic and therapeutic biomarker for lung adenocarcinoma, is associated with epithelial-mesenchymal transition and immune evasion. J Transl Med. 2023;21(1):909. Published 2023 Dec 12. doi:10.1186/s12967-023-04616-3.（中科院2区TOP）

(6)Liu Y, Zhou J, Wu J, et al. Construction and Validation of a Novel Immune-Related Gene Pairs-Based Prognostic Model in Lung Adenocarcinoma. Cancer Control. 2023;30:10732748221150227. doi:10.1177/10732748221150227.

(7)Liu, Y., Zhou, J., Wu, J., Wang, W., Wang, X., Guo, J., Wang, Q., Zhang, X., Li, D., Xie, J., Ding, X., Xing, Y., & Hu, D. (2022). Development and Validation of Machine Learning Models to Predict Epidermal Growth Factor Receptor Mutation in Non-Small Cell Lung Cancer: A Multi-Center Retrospective Radiomics Study. Cancer control : journal of the Moffitt Cancer Center, 29, 10732748221092926. 

(8)Liu Y, Hu C, Wu J, Zhou J, Wang W, Wang X, Guo J, Wang Q, Zhang X, Xie J, Xing Y, Ding X, Hu D. Relationship between lymphocyte to monocyte ratio and brain metastasis in non-smalll cell lung cancer patients. Am J Transl Res. 2022 Jun 15;14(6):3936-3945. PMID: 35836908; PMCID: PMC9274570.

(9)Yafeng L, Jing W*, Jiawei Z, Yingru X, Xin Z, Danting L, Jun X, Chang T, Min M, Xuansheng D*, Dong H*. Construction and Verification of a Radiation Pneumonia Prediction Model Based on Multiple Parameters. Cancer Control. 2021 Jan-Dec;28:10732748211026671. doi:10.1177/10732748211026671. 

共同一作

(1)Han T, Liu Y, Zhou J, et al. Development of an invasion score based on metastasis-related pathway activity profiles for identifying invasive molecular subtypes of lung adenocarcinoma. Sci Rep. 2024;14(1):1692. Published 2024 Jan 19. doi:10.1038/s41598-024-51681-9

(2)Han T, Liu Y, Wu J, et al. An immune indicator based on BTK and DPEP2 identifies hot and cold tumors and clinical treatment outcomes in lung adenocarcinoma. Sci Rep. 2023;13(1):5153. Published 2023 Mar 29. doi:10.1038/s41598-023-32276-2

(3)Bai Y, Liu Y, Wu J, et al. CD4 levels and NSCLC metastasis: the benefits of maintaining moderate levels. J Cancer Res Clin Oncol. 2023;149(18):16827-16836. doi:10.1007/s00432-023-05418-2

(4) Li W, Liu Y, Liu W, et al. Machine Learning-Based Prediction of Lymph Node Metastasis Among Osteosarcoma Patients. Front Oncol. 2022;12:797103. Published 2022 Apr 20. doi:10.3389/fonc.2022.797103

(5) Zhang W, Liu Y, Wu J, et al. Surgical Treatment is Still Recommended for Patients Over 75 Years with IA NSCLC: A Predictive Model Based on Surveillance, Epidemiology and End Results Database. Cancer Control. 2022;29:10732748221142750. doi:10.1177/10732748221142750

(6) Guo, J., Liu, Y., Hu, C., Zhang, W., Zhou, J., Wang, Q., Xing, Y., Hu, D., & Wu, J. (2022). Long-term exposure to dust and noise can increase the risk of hypertension-a population-based, cross-sectional study. Journal of occupational and environmental medicine, 10.1097/JOM.0000000000002769. 

二、论著之外的代表性研究成果和学术奖励：

(1) HU Dong, WU Jing, LIU Yafeng, ZHOU Jiawei, WANG Wenyang, XING Yingru, GUO Jianqiang, WANG Qingse; CT RADIOMICS-BASED AUXILIARY ASSESSMENT METHOD AND SYSTEM FOR LUNG CANCER PROGNOSIS , 2022-2-23, South Africa, 2021/05543 (国际专利)

(2) 一种辅助勾画胸部放射治疗靶区的软件, 2021-08-08, 中国, 2021SR155482 (软件著作权)